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A study published in March of 2011 showed that low levels of vitamin D failed to inhibit the inflammatory cascade and that normal levels did. Levels of inflmamatory cytokines interlukin 6 and TNF-alpha correlated with low levels of vitamin D. The vitamin D receptor binds to DNA directly and activates a gene MKP-1 which quiets the inflammatory response.
It could be that chronic inflammatory diseases such as asthma arthritis and even cancer could benefit from maintaining a normal vitamin D level.
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